Phenotypes Associated with This Genotype

Genotype
MGI:4355951

• Allelic Composition: Ccr2^tm1Mae/Ccr2^tm1Mae
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:311042 )

• in mice exposed to CCL4

decreased susceptibility to injury ( J:311042 )

• mice exposed to CCL4 exhibit attenuated livery injury and fibrosis with reduced alanine transferase (ALT) levels compared with wild-type mice

immune system

abnormal leukocyte migration ( J:171379 )

• LPS-induced monocyte emigration is decreased compared to in similarly treated wild-type mice

impaired macrophage chemotaxis ( J:151874 , J:191510 )

• very few macrophages are recruited in response to induced peritonitis (J:151874)

• recruitment of macrophages in mice homozygous for Ccl2^tm1Lex is impaired recruitment compared with recruitment of wild-type cells (J:191510)

abnormal chemokine secretion ( J:151874 )

• there is over a 2-fold increase in Ccl2 and Ccl7 secretion by activated macrophages compared to controls

cellular

abnormal leukocyte migration ( J:171379 )

• LPS-induced monocyte emigration is decreased compared to in similarly treated wild-type mice

impaired macrophage chemotaxis ( J:151874 , J:191510 )

• very few macrophages are recruited in response to induced peritonitis (J:151874)

• recruitment of macrophages in mice homozygous for Ccl2^tm1Lex is impaired recruitment compared with recruitment of wild-type cells (J:191510)

hematopoietic system

abnormal leukocyte migration ( J:171379 )

• LPS-induced monocyte emigration is decreased compared to in similarly treated wild-type mice

impaired macrophage chemotaxis ( J:151874 , J:191510 )

• very few macrophages are recruited in response to induced peritonitis (J:151874)

• recruitment of macrophages in mice homozygous for Ccl2^tm1Lex is impaired recruitment compared with recruitment of wild-type cells (J:191510)