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Phenotypes Associated with This Genotype
Genotype
MGI:4355902
Allelic
Composition
Tg(GFAP-tTA)67Pop/0
Tg(tetO-Ifng)184Pop/0
Genetic
Background
involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(GFAP-tTA)67Pop mutation (0 available)
Tg(tetO-Ifng)184Pop mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• when doxycycline treatment is stopped at E 16, around 90% of double mutants develop medulloblastoma and die by P21

neoplasm
• when doxycycline treatment is stopped at E 16, around 90% of double mutants develop medulloblastoma and die by P21

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:94092


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory