About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4355202
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Il10tm1Roer/Il10tm1Roer
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Il10tm1Roer mutation (1 available); any Il10 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:151551 )
• increased B cell numbers are observed after immunization with anti-IgD antibody compared to immunized controls
increased plasma cell number ( J:151551 )
• plasma cell numbers are 2-fold larger than controls seven days after infection with MCMV
increased CD4-positive, alpha-beta T cell number ( J:151551 )
• are observed after immunization with anti-IgD antibody compared to immunized controls
abnormal myeloid leukocyte morphology ( J:151551 )
• increased myeloid numbers are observed after immunization with anti-IgD antibody compared to immunized controls
abnormal CD8-positive, alpha-beta T cell physiology ( J:151551 )
• MCMV-specific CD8 + T cell numbers are about twice as numerous as controls 7 days after infection with MCMV
decreased circulating interleukin-10 level ( J:151551 )
• IL-10 levels are half that of wild-type controls when immunized with anti-IgD antibodies

homeostasis/metabolism
decreased circulating interleukin-10 level ( J:151551 )
• IL-10 levels are half that of wild-type controls when immunized with anti-IgD antibodies

hematopoietic system
increased B cell number ( J:151551 )
• increased B cell numbers are observed after immunization with anti-IgD antibody compared to immunized controls
increased plasma cell number ( J:151551 )
• plasma cell numbers are 2-fold larger than controls seven days after infection with MCMV
increased CD4-positive, alpha-beta T cell number ( J:151551 )
• are observed after immunization with anti-IgD antibody compared to immunized controls
abnormal myeloid leukocyte morphology ( J:151551 )
• increased myeloid numbers are observed after immunization with anti-IgD antibody compared to immunized controls
abnormal CD8-positive, alpha-beta T cell physiology ( J:151551 )
• MCMV-specific CD8 + T cell numbers are about twice as numerous as controls 7 days after infection with MCMV

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory