Phenotypes Associated with This Genotype

Genotype
MGI:4355022

• Allelic Composition: Atr^tm1Ofc/Atr^tm1Ofc; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:151542 )

• mice do not survive beyond 2 months

prenatal lethality, incomplete penetrance ( J:151542 )

• few mice are born

premature aging ( J:151542 )

• mice exhibit a more severe premature aging syndrome than in Atr^tm1Ofc homozygotes

skeleton

micrognathia ( J:151542 )

kyphosis ( J:151542 )

osteoporosis ( J:151542 )

growth/size/body

decreased body weight ( J:151542 )

small thoracic cavity ( J:151542 )

microcephaly ( J:151542 )

proportional dwarf ( J:151542 )

• more severe than in Atr^tm1Ofc homozygotes

cellular

increased embryonic tissue cell apoptosis ( J:151542 )

• apoptosis in the whole embryos is greater than in Atr^tm1Ofc homozygotes

abnormal DNA replication ( J:151542 )

• embryos exhibit replicative stress-initiated DNA damage response unlike wild-type mice

homeostasis/metabolism

abnormal DNA replication ( J:151542 )

• embryos exhibit replicative stress-initiated DNA damage response unlike wild-type mice

craniofacial

micrognathia ( J:151542 )

hematopoietic system

pancytopenia ( J:151542 )

embryo

increased embryonic tissue cell apoptosis ( J:151542 )

• apoptosis in the whole embryos is greater than in Atr^tm1Ofc homozygotes