Phenotypes Associated with This Genotype

Genotype
MGI:4354509

• Allelic Composition: Cd44^tm2Kmz/Cd44^tm2Kmz; Sell^tm2Hyn/Sell^tm2Hyn
• Genetic Background: involves: 129S2/SvPas * BALB/c * DBA/1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte adhesion ( J:114317 )

• the number of adherent leukocytes observed in the postcapillary venules of inflamed ears is 3-fold less than controls from 1 hour to 24 hours after immunization

impaired leukocyte tethering or rolling ( J:114317 )

• less rolling leukocytes are observed in the postcapillary venules of inflamed ears six hours after immunization compared to controls

• velocity of these rolling leukocytes is greater than controls 24 hours after immunization

impaired neutrophil recruitment ( J:114317 )

• about 4-fold less Gr⁺ cells are found in inflamed ears compared to controls

abnormal CD4-positive, alpha-beta T cell physiology ( J:114317 )

• about 2-3 fold less CD4⁺ T cells are recruited to inflamed ears compared to controls

decreased susceptibility to type IV hypersensitivity reaction ( J:114317 )

• OVA-sensitized mice have less swelling 12 to 24 hours after OVA injection in the ear compared to controls

cellular

abnormal leukocyte adhesion ( J:114317 )

• the number of adherent leukocytes observed in the postcapillary venules of inflamed ears is 3-fold less than controls from 1 hour to 24 hours after immunization

impaired leukocyte tethering or rolling ( J:114317 )

• less rolling leukocytes are observed in the postcapillary venules of inflamed ears six hours after immunization compared to controls

• velocity of these rolling leukocytes is greater than controls 24 hours after immunization

hematopoietic system

abnormal leukocyte adhesion ( J:114317 )

• the number of adherent leukocytes observed in the postcapillary venules of inflamed ears is 3-fold less than controls from 1 hour to 24 hours after immunization

impaired leukocyte tethering or rolling ( J:114317 )

• less rolling leukocytes are observed in the postcapillary venules of inflamed ears six hours after immunization compared to controls

• velocity of these rolling leukocytes is greater than controls 24 hours after immunization

impaired neutrophil recruitment ( J:114317 )

• about 4-fold less Gr⁺ cells are found in inflamed ears compared to controls

abnormal CD4-positive, alpha-beta T cell physiology ( J:114317 )

• about 2-3 fold less CD4⁺ T cells are recruited to inflamed ears compared to controls