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Phenotypes Associated with This Genotype
Genotype
MGI:4353816
Allelic
Composition
Gt(ROSA)26Sortm2(SNCA*119)Djmo/Gt(ROSA)26Sortm2(SNCA*119)Djmo
Tg(Th-cre)1Tmd/0
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(SNCA*119)Djmo mutation (1 available); any Gt(ROSA)26Sor mutation (336 available)
Tg(Th-cre)1Tmd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• there are significant reductions in the levels of striatal dopamine (~32%), dihydroxyphenylacetic acid (~46%) and homovanillic acid (~33%) compared to controls at 10-11 months of age
• 5-HT levels are elevated in the prefrontal cortex at 10-11 months of age compared to controls

nervous system
• there are significant reductions in the levels of striatal dopamine (~32%), dihydroxyphenylacetic acid (~46%) and homovanillic acid (~33%) compared to controls at 10-11 months of age
• norepinephrine levels in the striatum are elevated at 10-11 months of age compared to controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 1, Autosomal Dominant; PARK1 168601 J:150777


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory