Phenotypes Associated with This Genotype

Genotype
MGI:4353813

• Allelic Composition: Dab1^scm/Dab1^scm
• Genetic Background: involves: C3HeB/FeJ * DC/Le

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cerebellum size is reduced in Dab1^scm/Dab1^scm mice

mortality/aging

decreased survivor rate ( J:37166 )

• mice that do survive live a normal lifespan

postnatal lethality ( J:37166 )

• unless litters are culled to reduce competition for food, a significant number of mutants die before weaning

growth/size/body

decreased body size ( J:37166 )

• size difference begins to show after 15 days of age

• mutant mice frequently cannot be weaned until 5-6 weeks of age; culling some normal siblings prior to weaning can assure survivability of mutant mice

behavior/neurological

tremors ( J:37166 )

• mice exhibit a whole-body tremor

abnormal motor coordination/balance ( J:37166 )

• phenotype is consistent throughout life

abnormal gait ( J:37166 )

reproductive system

male infertility ( J:37166 )

♂

nervous system

abnormal cerebellar foliation ( J:37166 )

• this layer is not seen or reduced

abnormal hippocampus morphology ( J:37166 )

• this area is severely disorganized

• the pyramidal cells are aligned in two or more wavy rows rather than in a single curving row

abnormal dentate gyrus morphology ( J:37166 )

• neurons are randomly scattered

abnormal hippocampus pyramidal cell morphology ( J:37166 )

abnormal cerebral cortex morphology ( J:37166 )

• this area lacks its normal six layered structure

• large pyramidal cells and small granule cells are scattered rather than segregated into specific layers

abnormal stratification in cerebral cortex ( J:37166 )

abnormal cerebellar Purkinje cell layer ( J:37166 )

• a layer is not seen; Purkinje cells are scattered throughout the granule layer and beneath it

small cerebellum ( J:37166 )

• greatly reduced in size compared with normal littermates