Dab1^scm
Spontaneous Allele Detail

Summary

• Symbol: Dab1^scm
• Name: disabled 1; scrambler
• MGI ID: MGI:1856801
• Synonyms: scm
• Gene: Dab1 Location: Chr4:103476556-104602041 bp, + strand Genetic Position: Chr4, 47.79 cM
• Alliance: Dab1^scm page

Cerebellum size is reduced in Dab1^scm/Dab1^scm mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: DC/LeJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Transposon insertion
• Mutation details: Transcripts produced from this allele show abnormal splicing and are predicted to produce a truncated protein. Sequence analysis revealed that the larger scrambler transcript contains 1.5 kb of intracisternal A particle retrotransposon (IAP) sequence in antisense orientation. Previous mapping studies detcted an IAP particle that failed to recombine with the Dab1 locus. Thus, it appears that abberrant splicing has incorporated the IAP element in the coding region of the gene. (J:42628, J:43504)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dab1 Mutation: 77 strains or lines available

References

• Original: J:37166 Sweet HO, et al., Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration. Mamm Genome. 1996 Nov;7(11):798-802
• All: 30 reference(s)