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Phenotypes Associated with This Genotype
Genotype
MGI:4353423
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Fwa
Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Themis5AT161/Themis5AT161
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (48 available); any Rag2 mutation (117 available)
Tg(Tcra5CC7,Tcrb5CC7)IWep mutation (3 available)
Themis5AT161 mutation (0 available); any Themis mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased double-positive T cell number ( J:151076 )
• an increase in double positive thymocytes results from arrested thymocyte development
arrested T cell differentiation ( J:151076 )
• there is a complete block in CD4 single-positive thymocyte development
• the minor CD8 single-positive population in transgenic mice is also significantly affected

immune system
increased double-positive T cell number ( J:151076 )
• an increase in double positive thymocytes results from arrested thymocyte development
arrested T cell differentiation ( J:151076 )
• there is a complete block in CD4 single-positive thymocyte development
• the minor CD8 single-positive population in transgenic mice is also significantly affected

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory