Phenotypes Associated with This Genotype

Genotype
MGI:4353114

• Allelic Composition: Tg(TcraTcrb)1100Mjb/?; Themis^tm1Gasc/Themis^tm1Gasc
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal positive T cell selection ( J:151074 )

• thymocytes fail to exit the CD4^hiCD8^int stage to the CD8 single-positive stage

increased double-positive T cell number ( J:151074 )

• the proportion and number of double-positive thymocytes is greater than controls

decreased CD8-positive, alpha-beta T cell number ( J:151074 )

• very few single-positive thymocytes are generated in the thymus

hematopoietic system

abnormal positive T cell selection ( J:151074 )

• thymocytes fail to exit the CD4^hiCD8^int stage to the CD8 single-positive stage

increased double-positive T cell number ( J:151074 )

• the proportion and number of double-positive thymocytes is greater than controls

decreased CD8-positive, alpha-beta T cell number ( J:151074 )

• very few single-positive thymocytes are generated in the thymus