Analysis Tools
immune system
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• more cells in the white pulp undergo apoptosis than in wild-type mice
• however, stimulated B cells in the spleen exhibit normal levels of apoptosis
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• in LPS, anti-IgD-dextran, and anti-CD40 treated cells in the presence of IL4 and IL5
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• 50% to 80% in the spleen as early as 1 week after birth
• the number of B cells in the bone marrow declines 50% between 8 and 12 weeks unlike in wild-type mice
• however, both mature and immature B cells are detected
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• spleen architecture is disrupted with diffuse, irregular B cell areas and absent perifollicular marginal zone and germinal centers unlike in wild-type mice
• sheep red blood cell-imminized mice exhibit very few germinal center cells and diffuse perifollicular staining of cells expressing surface IgD unlike in similarly treated wild-type mice
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• sheep red blood cell-imminized mice exhibit reduced numbers of metallophillic macrophages scattered throughout the white matter unlike in similarly treated wild-type mice
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• in mice immunized with a variety of antigens, including sheep red blood cells and NP-KLH
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• 2-fold in naive cell
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• following immunization with NP-KLH, mice exhibit a 4-fold and 10-fold reduction at days 7 and 10, respectively, in NP-specific isotype IgG1 compared to in similarly treated wild-type mice
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• 2.5-fold in naive cells
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• in naive cells, IgG3 is reduced 3-fold compared to in wild-type mice
• following immunization with NP-LPS, mice exhibit a 10-fold and 30-fold reduction at days 7 and 21, respectively, in NP-specific IgG3 compared to in similarly treated wild-type mice
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• 4.5-fold in naive cells and 2 times higher in response to distinct stimuli compared to in wild-type mice
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• lymph nodes exhibit similar morphological abnormalities as those observed in the spleen
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hematopoietic system
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• more cells in the white pulp undergo apoptosis than in wild-type mice
• however, stimulated B cells in the spleen exhibit normal levels of apoptosis
|
|
• in LPS, anti-IgD-dextran, and anti-CD40 treated cells in the presence of IL4 and IL5
|
|
• 50% to 80% in the spleen as early as 1 week after birth
• the number of B cells in the bone marrow declines 50% between 8 and 12 weeks unlike in wild-type mice
• however, both mature and immature B cells are detected
|
|
• spleen architecture is disrupted with diffuse, irregular B cell areas and absent perifollicular marginal zone and germinal centers unlike in wild-type mice
• sheep red blood cell-imminized mice exhibit very few germinal center cells and diffuse perifollicular staining of cells expressing surface IgD unlike in similarly treated wild-type mice
|
|
• sheep red blood cell-imminized mice exhibit reduced numbers of metallophillic macrophages scattered throughout the white matter unlike in similarly treated wild-type mice
|
|
• in mice immunized with a variety of antigens, including sheep red blood cells and NP-KLH
|
|
• 2-fold in naive cell
|
|
• following immunization with NP-KLH, mice exhibit a 4-fold and 10-fold reduction at days 7 and 10, respectively, in NP-specific isotype IgG1 compared to in similarly treated wild-type mice
|
|
• 2.5-fold in naive cells
|
|
• in naive cells, IgG3 is reduced 3-fold compared to in wild-type mice
• following immunization with NP-LPS, mice exhibit a 10-fold and 30-fold reduction at days 7 and 21, respectively, in NP-specific IgG3 compared to in similarly treated wild-type mice
|
|
• 4.5-fold in naive cells and 2 times higher in response to distinct stimuli compared to in wild-type mice
|
cellular
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• more cells in the white pulp undergo apoptosis than in wild-type mice
• however, stimulated B cells in the spleen exhibit normal levels of apoptosis
|
|
• in LPS, anti-IgD-dextran, and anti-CD40 treated cells in the presence of IL4 and IL5
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| common variable immunodeficiency | DOID:12177 |
OMIM:PS607594 |
J:206674 | |
