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Phenotypes Associated with This Genotype
Genotype
MGI:3852467
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
B6.Cg-Ptpn11tm1.1Rbns Gt(ROSA)26Sortm1Sor H2az2Tg(Wnt1-cre)11Rth
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (10 available); any Gt(ROSA)26Sor mutation (1062 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Ptpn11tm1.1Rbns mutation (0 available); any Ptpn11 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• at E12.5, the number of neural crest cells in the outflow tract cushions are less than in wild-type mice
• at E17.5, the number of neural crest cells in the proximal outflow tract is less than in wild-type mice
• however, initial proliferation and migration are normal
• cranial neural crest cells fail to differentiate into osteoblasts unlike in wild-type mice

nervous system
• at E12.5, the number of neural crest cells in the outflow tract cushions are less than in wild-type mice
• at E17.5, the number of neural crest cells in the proximal outflow tract is less than in wild-type mice
• however, initial proliferation and migration are normal
• cranial neural crest cells fail to differentiate into osteoblasts unlike in wild-type mice

cardiovascular system
• at E12.5, the number of neural crest cells in the outflow tract cushions are less than in wild-type mice
• at E17.5, the number of neural crest cells in the proximal outflow tract is less than in wild-type mice
• however, initial proliferation and migration are normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory