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Phenotypes Associated with This Genotype
Genotype
MGI:3852220
Allelic
Composition
Gpd2tm1Tka/Gpd2tm1Tka
Slc25a13tm1Lct/Slc25a13tm1Lct
Genetic
Background
B6.Cg-Gpd2tm1Tka Slc25a13tm1Lct
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpd2tm1Tka mutation (0 available); any Gpd2 mutation (49 available)
Slc25a13tm1Lct mutation (0 available); any Slc25a13 mutation (135 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• hepatic aspartic acid levels are higher than in wild-type mice

mortality/aging
• 30% fewer than expected mice are found between 20 and 40 days

homeostasis/metabolism
• hepatic aspartic acid levels are higher than in wild-type mice
• citrulline and threonine/serine ratios are higher than in wild-type mice
• following oral sucrose administration, the plasma alanine concentration and branched amino acid/aromatic amino acid ratio are decreased compared to in wild-type mice
• under fed conditions and after oral sucrose administration
• plasma urea concentrations are higher than in wild-type mice
• compared to in wild-type mice and more severely than in Slc25a13tm1Lct homozygotes under fasting and fed conditions
• compared to wild-type mice and more severely than in Gpd2tm1Tka homozygotes

liver/biliary system
• following 16 hours of fasting

growth/size/body
• by 36 days in males and 29 days in females

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
citrullinemia DOID:9273 OMIM:215700
OMIM:603471
OMIM:605814
J:124766


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory