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Phenotypes Associated with This Genotype
Genotype
MGI:3852090
Allelic
Composition		 Cd22tm1Eac/Cd22+
Ptpn6me-v/Ptpn6+
Tg(IghelMD4)4Ccg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Eac mutation (1 available); any Cd22 mutation (59 available)
Ptpn6me-v mutation (4 available); any Ptpn6 mutation (47 available)
Tg(IghelMD4)4Ccg mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell negative selection ( J:110531 )
• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is partially blocked at the immature B cell stage
abnormal mature B cell morphology ( J:110531 )
• surface expression of IgM is less than half of controls

hematopoietic system
abnormal B cell negative selection ( J:110531 )
• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is partially blocked at the immature B cell stage
abnormal mature B cell morphology ( J:110531 )
• surface expression of IgM is less than half of controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory