Phenotypes Associated with This Genotype

Genotype
MGI:3852084

• Allelic Composition: Lyn^tm1Ard/Lyn^tm1Ard; Tg(IghelMD4)4Ccg/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is blocked at the immature B cell stage instead of anergy inducation in mature B cells as occurs with wild-type bone marrow

abnormal mature B cell morphology ( J:110531 )

• mature B cells have 4-5 lower sIgM levels on their surface

absent B-1 B cells ( J:110531 )

• B1 B cells are absent in these mice

abnormal B cell activation ( J:110531 )

• B cells have altered kinetics of calcium fluxing upon BCR engagement with delayed influx but an ultimately higher peak intracellular concentration

increased IgM level ( J:110531 )

• hypersecretion of the transgenic IgM antibody occurs in these mice

hematopoietic system

abnormal B cell negative selection ( J:110531 )

• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is blocked at the immature B cell stage instead of anergy inducation in mature B cells as occurs with wild-type bone marrow

abnormal mature B cell morphology ( J:110531 )

• mature B cells have 4-5 lower sIgM levels on their surface

absent B-1 B cells ( J:110531 )

• B1 B cells are absent in these mice

abnormal B cell activation ( J:110531 )

• B cells have altered kinetics of calcium fluxing upon BCR engagement with delayed influx but an ultimately higher peak intracellular concentration

increased IgM level ( J:110531 )

• hypersecretion of the transgenic IgM antibody occurs in these mice