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Phenotypes Associated with This Genotype
Genotype
MGI:3851989
Allelic
Composition		 Il10tm1Cgn/Il10tm1Cgn
Il12btm1Jm/Il12btm1Jm
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10tm1Cgn mutation (15 available); any Il10 mutation (43 available)
Il12btm1Jm mutation (4 available); any Il12b mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T-helper 2 cell differentiation ( J:111712 )
• mice exhibit enhanced Th2 responses after infection with S. mansoni eggs compared to controls

immune system
abnormal T-helper 2 cell differentiation ( J:111712 )
• mice exhibit enhanced Th2 responses after infection with S. mansoni eggs compared to controls
increased interleukin-13 secretion ( J:111712 )
• there is a 200- to 250-fold increase in IL-13 mRNA present in the lungs after infection with S. mansoni eggs

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory