Phenotypes for Il4 Il10 MGI:3851988 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Il10^tm1Cgn/Il10^tm1Cgn Il4^tm1Cgn/Il4^tm1Cgn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10^tm1Cgn mutation (15 available); any Il10 mutation (44 available)
Il4^tm1Cgn mutation (4 available); any Il4 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T-helper 1 cell differentiation ( J:111712 )

• mice exhibit enhanced Th1 responses after infection with S. mansoni eggs compared to controls

increased interferon-gamma secretion ( J:111712 )

• there is a 75-fold increase in IFN-gamma mRNA in the lungs after infection with S. mansoni eggs

hematopoietic system

abnormal T-helper 1 cell differentiation ( J:111712 )

• mice exhibit enhanced Th1 responses after infection with S. mansoni eggs compared to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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