Mouse Genome Informatics
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Hair coat abnormalities in HrHp/Hr+ and HrHp/HrHp mice

• as early as P7
• by P21, hair shafts are abnormal
• hair shafts fail to penetrate the skin
• hair follicle abnormalities become more severe with age
• vibrissa hair follicles are normal
• the dermal papilla of the hair follicle is located at the border between subcutis and dermis
• by P21, mice exhibit histomorphologically disrupted inner root sheath
• vibrissa are thinner than normal and lack hair fiber compared to in wild-type mice
• vibrissa are shorter than in wild-type mice
• epidermal epithelial cell growth is reduced and cavernous sinus is expanded compared to in wild-type mice
• more severe than in heterozygous mice
• by P21, mice exhibit eosin-staining cyst-like structures
• at P210, the skin is filled with cysts
• at P21, skin thickness is reduced

Mouse Models of Human Disease
Hypotrichosis 4; HYPT4 146550 J:150720