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Phenotypes Associated with This Genotype
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
HrHp mutation (0 available); any Hr mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Hair coat abnormalities in HrHp/Hr+ and HrHp/HrHp mice

• as early as P7
• by P21, hair shafts are abnormal
• hair shafts fail to penetrate the skin
• hair follicle abnormalities become more severe with age
• vibrissa hair follicles are normal
• the dermal papilla of the hair follicle is located at the border between subcutis and dermis
• by P21, mice exhibit histomorphologically disrupted inner root sheath
• vibrissa are thinner than normal and lack hair fiber compared to in wild-type mice
• vibrissa are shorter than in wild-type mice
• epidermal epithelial cell growth is reduced and cavernous sinus is expanded compared to in wild-type mice
• more severe than in heterozygous mice
• by P21, mice exhibit eosin-staining cyst-like structures
• at P210, the skin is filled with cysts
• at P21, skin thickness is reduced

Mouse Models of Human Disease
OMIM ID Ref(s)
Hypotrichosis 4; HYPT4 146550 J:150720

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory