Phenotypes Associated with This Genotype

Genotype
MGI:3851809

• Allelic Composition: Pex5^tm1Pec/Pex5^tm1Pec; Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal testis morphology ( J:108368 )

♂

abnormal seminiferous tubule morphology ( J:108368 )

♂ • large numbers of lipid drops present at 10 days and 7 weeks

seminiferous tubule degeneration ( J:108368 )

♂ • spermatozoa still present at 7 weeks

♂ • progressive degeneration of seminiferous tubules from 9-11 weeks

decreased testis weight ( J:108368 )

♂ • testicular weight 30-40% of normal controls at 14 weeks

male infertility ( J:108368 )

♂ • 6-13 week old males mate but fail to sire offspring

endocrine/exocrine glands

abnormal testis morphology ( J:108368 )

♂

abnormal seminiferous tubule morphology ( J:108368 )

♂ • large numbers of lipid drops present at 10 days and 7 weeks

seminiferous tubule degeneration ( J:108368 )

♂ • spermatozoa still present at 7 weeks

♂ • progressive degeneration of seminiferous tubules from 9-11 weeks

decreased testis weight ( J:108368 )

♂ • testicular weight 30-40% of normal controls at 14 weeks