Phenotypes Associated with This Genotype

Genotype
MGI:3851804

• Allelic Composition: Fas^lpr/Fas^lpr
• Genetic Background: involves: MRL/Mp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:50903 )

• mice exhibit increased Pseudomonas aerugiosa exotoxin-induced mortality compared with similarly treated wild-type mice

immune system

decreased macrophage apoptosis ( J:154647 )

• macrophages exhibit 60% less cholesterol-induced apoptosis compared with similarly treated wild-type cells

increased susceptibility to bacterial infection ( J:50903 )

• mice exhibit increased Pseudomonas aerugiosa exotoxin-induced mortality compared with similarly treated wild-type mice

cellular

decreased macrophage apoptosis ( J:154647 )

• macrophages exhibit 60% less cholesterol-induced apoptosis compared with similarly treated wild-type cells

hematopoietic system

decreased macrophage apoptosis ( J:154647 )

• macrophages exhibit 60% less cholesterol-induced apoptosis compared with similarly treated wild-type cells