Phenotypes Associated with This Genotype

Genotype
MGI:3851800

• Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1Dor; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

decreased embryo size ( J:150706 )

• E12.5 embryos are noticeably smaller than controls

growth/size/body

decreased embryo size ( J:150706 )

• E12.5 embryos are noticeably smaller than controls

respiratory system

abnormal lung development ( J:150706 )

• apoptosis is expanded caudally in the bronchial epithelium compared to controls at E11.25

• widespread apoptosis occurs in the lung epithelium by E12.5 and is also observed in the lung mesenchyme

impaired branching involved in bronchus morphogenesis ( J:150706 )

• some E11.5 embryos have smaller lung branches with a bumpy, irregular morphology

• by E12.5, irregular outgrowths have arisen along the entire length of both main bronchi of the mutant lungs with outgrowths concentrated more caudally

• mesenchymal protrusions without an accompanying epithelial branch are occasionally observed during embryonic development