Phenotypes Associated with This Genotype

Genotype
MGI:3851733

• Allelic Composition: Brca1^tm1Rfo/Brca1^tm1Rfo
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:67880 )

• homozygotes die in mid gestation, between 9.5 and 10.5 dpc, due to massive apoptosis throughout the embryo

embryo

abnormal developmental patterning ( J:69602 )

• no further development after E10.5

embryonic growth retardation ( J:69602 )

• at E8.5

abnormal embryonic tissue morphology ( J:69602 )

• embryonic components small at E8.5

incomplete somite formation ( J:69602 )

• few somites present at E9.5

• no further development at E10.5

enlarged tail bud ( J:69602 )

• greatly enlarged at E9.5

cardiovascular system

abnormal heart development ( J:69602 )

• heart structures are formed by E9.5

• no further development at E10.5

limbs/digits/tail

enlarged tail bud ( J:69602 )

• greatly enlarged at E9.5

cellular

increased apoptosis ( J:69602 )

• large numbers of apoptotic bodies can be found at E10.5

growth/size/body

embryonic growth retardation ( J:69602 )

• at E8.5