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Phenotypes Associated with This Genotype
Genotype
MGI:3851695
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Ikbkgtm1.1Mpa/Y
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Ikbkgtm1.1Mpa mutation (1 available); any Ikbkg mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• B cell turnover over a one week period is twice that of controls
• immature B cell numbers in the spleen are reduced by about a third
• there is a 2- to 4- fold reduction in the number of mature recirculating B cells found in the bone marrow
• the IgMlowIgD+ mature B cell population is strongly diminished in the spleen by 3- to 4- fold
• B cell numbers in the lymph nodes are also strongly reduced
• B-1 B cell numbers are strongly decreased in the peritoneum cavity
• follicular B cells are the most diminished B cell population in the spleen
• marginal zone B cell numbers are reduced about 4-fold

hematopoietic system
• B cell turnover over a one week period is twice that of controls
• immature B cell numbers in the spleen are reduced by about a third
• there is a 2- to 4- fold reduction in the number of mature recirculating B cells found in the bone marrow
• the IgMlowIgD+ mature B cell population is strongly diminished in the spleen by 3- to 4- fold
• B cell numbers in the lymph nodes are also strongly reduced
• B-1 B cell numbers are strongly decreased in the peritoneum cavity
• follicular B cells are the most diminished B cell population in the spleen
• marginal zone B cell numbers are reduced about 4-fold

cellular
• B cell turnover over a one week period is twice that of controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory