Phenotypes Associated with This Genotype

Genotype
MGI:3851559

• Allelic Composition: Tg(EEF1A1-SHC1*)1Ravi/?; Tg(Lck-cre)1Cwi/?
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hypoplasia ( J:78180 )

• thymus cellularity is only 10-30% of controls

abnormal double-negative T cell morphology ( J:78180 )

• double-negative thymocyte numbers are similar to wild-type but the distribution of the sub-populations differs

• mice have a 83% DN3 stage thymocytes compared to 48% in normal mice, with a concomitant decrease in the DN4 stage thymocytes (46% in normal versus 8% in double-transgenic mice)

• these DN3 cells have less proliferation suggesting a partial block in development

decreased double-positive T cell number ( J:78180 )

• double-positive thymocyte numbers are decreased compared to wild-type while double-negative numbers are close to normal

decreased single-positive T cell number ( J:78180 )

• single-positive thymocyte numbers are decreased compared to controls

hematopoietic system

thymus hypoplasia ( J:78180 )

• thymus cellularity is only 10-30% of controls

abnormal double-negative T cell morphology ( J:78180 )

• double-negative thymocyte numbers are similar to wild-type but the distribution of the sub-populations differs

• mice have a 83% DN3 stage thymocytes compared to 48% in normal mice, with a concomitant decrease in the DN4 stage thymocytes (46% in normal versus 8% in double-transgenic mice)

• these DN3 cells have less proliferation suggesting a partial block in development

decreased double-positive T cell number ( J:78180 )

• double-positive thymocyte numbers are decreased compared to wild-type while double-negative numbers are close to normal

decreased single-positive T cell number ( J:78180 )

• single-positive thymocyte numbers are decreased compared to controls

endocrine/exocrine glands

thymus hypoplasia ( J:78180 )

• thymus cellularity is only 10-30% of controls