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Phenotypes Associated with This Genotype
Genotype
MGI:3851519
Allelic
Composition		 Nkx2-5tm1(cre)Rjs/Nkx2-5+
Nsd2tm1Ykan/Nsd2+
Genetic
Background		 involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
Nsd2tm1Ykan mutation (0 available); any Nsd2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal interatrial septum morphology ( J:150360 )
• hypoplasia of the septum secundum was observed more frequently in E18.5 embryos than in controls
atrial septal defect ( J:150360 )
• one-third of E18.5 embryos have atrial septum defects
perimembraneous ventricular septal defect ( J:150360 )
• one-third of E18.5 embryos have membranous ventricular septum defects

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory