Phenotypes Associated with This Genotype

Genotype
MGI:3851498

• Allelic Composition: Shh^tm1Amc/Shh^tm1.1Rseg
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryo phenotype ( J:150524 )

N • while organ size is reduced to various degrees, all organs are present and correctly localized unlike in Shh-null mice

growth/size/body

decreased body weight ( J:150524 )

• body weight of mice is greatly reduced compared to controls

nervous system

decreased brain weight ( J:150524 )

• brain weight is less than controls

small olfactory bulb ( J:150524 )

• olfactory bulb is disproportionately smaller than controls

cerebellum hypoplasia ( J:150524 )

• cerebella is 50% smaller than controls, which is disproportionately smaller compared to other organs

vision/eye

microphthalmia ( J:150524 )

• eyes are small but are well-spaced unlike Shh-null mice that have improperly spaced eyes