Phenotypes Associated with This Genotype

Genotype
MGI:3851399

• Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho; Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal heart development and coronary vasculogenesis in Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Zfpm2^tm1Sho/Zfpm2^tm2Sho mice

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:150452 )

• embryos die by E13.5-E14.5

cardiovascular system

thin myocardium compact layer ( J:150452 )

• compact myocardium is thin

abnormal atrioventricular cushion morphology ( J:150452 )

• atrio-ventricular cushion defect is observed

abnormal coronary vessel morphology ( J:150452 )

• coronary vascular plexus is significantly decreased compared to controls; myocardium contains few coronary vessels

overriding aortic valve ( J:150452 )

atrial septal defect ( J:150452 )

• large atrial septal defect is observed in embryos

ventricular septal defect ( J:150452 )

• large ventricular septal defect is observed

pericardial effusion ( J:150452 )

• embryos display pericardial effusion prior to death

hemorrhage ( J:150452 )

• embryos display hemorrhage prior to death

homeostasis/metabolism

pericardial effusion ( J:150452 )

• embryos display pericardial effusion prior to death

skin edema ( J:150452 )

• embryos develop subcutaneous edema prior to death

integument

skin edema ( J:150452 )

• embryos develop subcutaneous edema prior to death

muscle

thin myocardium compact layer ( J:150452 )

• compact myocardium is thin