Analysis Tools
mortality/aging
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• 50% of mice die by 13 weeks
• 92% of mice die by 36 weeks
• 9 of 10 mice die during the tonic phase of an audiogenic seizure due to respiratory arrest
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reproductive system
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• sperm maturation is defective
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nervous system
| N |
• mice exhibit no neuronal cell loss or demyelination
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• some mice exhibit spontaneous and/or handling-induced seizures unlike wild-type mice
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• beginning as a brief wild-running phase and followed by a clonic-tonic seizure
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respiratory system
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• 9 of 10 mice die during the tonic phase of a seizure due to respiratory arrest
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behavior/neurological
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• some mice exhibit spontaneous and/or handling-induced seizures unlike wild-type mice
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• beginning as a brief wild-running phase and followed by a clonic-tonic seizure
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