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Phenotypes Associated with This Genotype
Genotype
MGI:3851236
Allelic
Composition
Tg(Acta2-RAC1*G12V)33Pjgc/Tg(Acta2-RAC1*G12V)33Pjgc
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Acta2-RAC1*G12V)33Pjgc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• at 8 months mice develop discolored reddish lesions mainly on the tail unlike wild-type mice (J:150015)
• mice develop Kaposi-like tumors with excessive proliferation of spindle cells without identifiable organized vascular structures inside the tumors but with slits containing red blood cells and hemosiderin between cells unlike in wild-type mice (J:150015)
• tumors prevalence is more severe in older, males homozygotes (J:150015)
• female mice develop Kaposi-like sarcomas later in life (mean age 18 months) (J:150015)
• tumors cells are positive for Kaposi sarcoma phenotypic markers CD31 and CD34 (J:150015)
• tumor cells secrete more IL6, IL8, TNF-alpha, MCP1, MIP1alpha, and KC than in smooth muscle cells (J:150015)
• tumors exhibit increased reactive oxygen species-mediated oxidative DNA damage compared to in wild-type cells (J:150015)
• tumors cells exhibit polyploidy and aneuploidy (J:150015)
• tumors exhibit a two-fold increase in reactive oxygen species production compared with wild-type cells (J:150015)
• tumor cell growth is inhibited by N-acetyl-cysteine and stimulated by hydrogen peroxide (J:150015)
• however, treatment with N-acetyl-cysteine prevents limits the development of tumors (J:150015)
• at 8 months mice develop discolored reddish lesions mainly on the tail unlike wild-type mice (J:150015)
• mice develop Kaposi-like tumors with excessive proliferation of spindle cells without identifiable organized vascular structures inside the tumors but with slits containing red blood cells and hemosiderin between cells unlike in wild-type mice (J:150015)
• tumors prevalence is more severe in older, males homozygotes (J:150015)
• female mice develop Kaposi-like sarcomas later in life (mean age 18 months) (J:150015)
• tumors cells are positive for Kaposi sarcoma phenotypic markers CD31 and CD34 (J:150015)
• tumor cells secrete more IL6, IL8, TNF-alpha, MCP1, MIP1alpha, and KC than in smooth muscle cells (J:150015)
• tumors exhibit increased reactive oxygen species-mediated oxidative DNA damage compared to in wild-type cells (J:150015)
• tumors cells exhibit polyploidy and aneuploidy (J:150015)
• tumors exhibit a two-fold increase in reactive oxygen species production compared with wild-type cells (J:150015)
• tumor cell growth is inhibited by N-acetyl-cysteine and stimulated by hydrogen peroxide (J:150015)
• however, treatment with N-acetyl-cysteine prevents limits the development of tumors (J:150015)

immune system
• tumor cells secrete more MCP1, MIP1alpha, and KC than in smooth muscle cells (J:150015)
• tumor cells secrete more MCP1, MIP1alpha, and KC than in smooth muscle cells (J:150015)
• in tumor cells compared with smooth muscle cells (J:150015)
• in tumor cells compared with smooth muscle cells (J:150015)
• in tumor cells compared with smooth muscle cells (J:150015)
• in tumor cells compared with smooth muscle cells (J:150015)

cellular
• in tumor cells (J:150015)
• in tumor cells (J:150015)
• in tumor cells (J:150015)
• in tumor cells (J:150015)
• tumors exhibit a two-fold increase in reactive oxygen species production compared with wild-type cells (J:150015)
• tumors exhibit a two-fold increase in reactive oxygen species production compared with wild-type cells (J:150015)

Mouse Models of Human Disease
OMIM ID Ref(s)
Kaposi Sarcoma, Susceptibility to 148000 J:150015


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory