Mouse Genome Informatics
tg
    Tg(Acta2-RAC1*G12V)33Pjgc/Tg(Acta2-RAC1*G12V)33Pjgc
involves: C57BL/6 * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• at 8 months mice develop discolored reddish lesions mainly on the tail unlike wild-type mice
• mice develop Kaposi-like tumors with excessive proliferation of spindle cells without identifiable organized vascular structures inside the tumors but with slits containing red blood cells and hemosiderin between cells unlike in wild-type mice
• tumors prevalence is more severe in older, males homozygotes
• female mice develop Kaposi-like sarcomas later in life (mean age 18 months)
• tumors cells are positive for Kaposi sarcoma phenotypic markers CD31 and CD34
• tumor cells secrete more IL6, IL8, TNF-alpha, MCP1, MIP1alpha, and KC than in smooth muscle cells
• tumors exhibit increased reactive oxygen species-mediated oxidative DNA damage compared to in wild-type cells
• tumors cells exhibit polyploidy and aneuploidy
• tumors exhibit a two-fold increase in reactive oxygen species production compared with wild-type cells
• tumor cell growth is inhibited by N-acetyl-cysteine and stimulated by hydrogen peroxide
• however, treatment with N-acetyl-cysteine prevents limits the development of tumors

immune system
• tumor cells secrete more MCP1, MIP1alpha, and KC than in smooth muscle cells
• in tumor cells compared with smooth muscle cells
• in tumor cells compared with smooth muscle cells

cellular
• in tumor cells
• in tumor cells
• tumors exhibit a two-fold increase in reactive oxygen species production compared with wild-type cells

Mouse Models of Human Disease
OMIM IDRef(s)
Kaposi Sarcoma, Susceptibility to 148000 J:150015