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Phenotypes Associated with This Genotype
Genotype
MGI:3851236
Allelic
Composition
Tg(Acta2-RAC1*G12V)33Pjgc/Tg(Acta2-RAC1*G12V)33Pjgc
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Acta2-RAC1*G12V)33Pjgc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• at 8 months mice develop discolored reddish lesions mainly on the tail unlike wild-type mice
• mice develop Kaposi-like tumors with excessive proliferation of spindle cells without identifiable organized vascular structures inside the tumors but with slits containing red blood cells and hemosiderin between cells unlike in wild-type mice
• tumors prevalence is more severe in older, males homozygotes
• female mice develop Kaposi-like sarcomas later in life (mean age 18 months)
• tumors cells are positive for Kaposi sarcoma phenotypic markers CD31 and CD34
• tumor cells secrete more IL6, IL8, TNF-alpha, MCP1, MIP1alpha, and KC than in smooth muscle cells
• tumors exhibit increased reactive oxygen species-mediated oxidative DNA damage compared to in wild-type cells
• tumors cells exhibit polyploidy and aneuploidy
• tumors exhibit a two-fold increase in reactive oxygen species production compared with wild-type cells
• tumor cell growth is inhibited by N-acetyl-cysteine and stimulated by hydrogen peroxide
• however, treatment with N-acetyl-cysteine prevents limits the development of tumors

immune system
• tumor cells secrete more MCP1, MIP1alpha, and KC than in smooth muscle cells
• in tumor cells compared with smooth muscle cells
• in tumor cells compared with smooth muscle cells

cellular
• in tumor cells
• in tumor cells
• tumors exhibit a two-fold increase in reactive oxygen species production compared with wild-type cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Kaposi Sarcoma, Susceptibility to 148000 J:150015


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory