Phenotypes Associated with This Genotype

Genotype
MGI:3851147

• Allelic Composition: Foxp2^tm2.1Woen/Foxp2^tm2.1Woen
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neurite morphology ( J:150425 )

• neurites are 80% longer than in wild-type cells

abnormal dendrite morphology ( J:150425 )

• dendritic trees of medium spiny neurons are 22% longer than in wild-type cells

abnormal synaptic plasticity ( J:150425 )

• long-term synaptic depression is twice as strong as in wild-type mice

abnormal long-term depression ( J:150425 )

• long-term synaptic depression is twice as strong as in wild-type mice

behavior/neurological

decreased exploration in new environment ( J:150425 )

• on a modified hole board, mice travel shorter distances at lower mean velocity; make fewer turns and line crosses; explore fewer holes; enter hole board less often; and stayed closer to the walls than wild-type mice

decreased vocalization ( J:150425 )

• start peak frequency, mean, minimum, and maximum of calls less than 50 ms are lower than in wild-type mice

• the slope of calls less than 50 ms declines less in frequency compared to in wild-type mice

cardiovascular system

cardiovascular system phenotype ( J:150425 )

N • unlike in Foxp2^tm1Woen mice, R-wave amplitudes are normal

homeostasis/metabolism

decreased dopamine level ( J:150425 )

• in the frontal cortex, cerebellum, caudate-putamen, nucleus accumbens, and globus pallidus