Phenotypes Associated with This Genotype

Genotype
MGI:3850728

• Allelic Composition: Rad52^tm1Aps/Rad52^tm1Aps; Rad54l^tm1Jhjh/Rad54l^tm1Jhjh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:101697 )

• following treatment with mitomycine C, mice exhibit increased lethality compared with similarly treated wild-type mice and Rad54l^tm1Jhjh homozygotes

hematopoietic system

abnormal definitive hematopoiesis ( J:101697 )

• following treatment with X-rays, mice exhibit severe hematopoietic depression compared with similarly treated wild-type mice and Rad54l^tm1Jhjh homozygotes

cellular

abnormal chromosome morphology ( J:101697 )

• following mitomycine C treatment, mice exhibit a small reduction in the frequency of sister chromatid exchange compared with similarly treated wild-type mice

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:101697 )

• following treatment with mitomycine C, mice exhibit increased lethality compared with similarly treated wild-type mice and Rad54l^tm1Jhjh homozygotes