Phenotypes Associated with This Genotype

Genotype
MGI:3850714

• Allelic Composition: Fos^{tm2(Fosl1)Wag}/Fos^{tm2(Fosl1)Wag}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:94200 )

N • mice exhibit normal general, exploratory, anxiety-related behaviors and contextual fear conditioning

abnormal spatial learning ( J:94200 )

• mice exhibit impaired performance in a Morris water maze

vision/eye

increased retina apoptosis ( J:65766 )

• mice exhibit increased light-induced retinal cell apoptosis compared with wild-type mice

nervous system

nervous system phenotype ( J:94200 )

N • unlike Fos null mice, LTP induction is normal

skeleton

skeleton phenotype ( J:65766 )

N • mice exhibit normal tooth eruption, osteoclast number, and bone architecture

growth/size/body

growth/size/body region phenotype ( J:65766 )

N • mice exhibit normal size and weight

cellular

increased retina apoptosis ( J:65766 )

• mice exhibit increased light-induced retinal cell apoptosis compared with wild-type mice