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Phenotypes Associated with This Genotype
Genotype
MGI:3850479
Allelic
Composition		 Nf2tm2Gth/Nf2tm2Gth
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased renal carcinoma incidence ( J:150071 )
• within 6 months of induction, lumen-filling renal tubule neoplasias are observed unlike in control mice
• tumors often block urinary flow

renal/urinary system
increased renal carcinoma incidence ( J:150071 )
• within 6 months of induction, lumen-filling renal tubule neoplasias are observed unlike in control mice
• tumors often block urinary flow

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory