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Phenotypes Associated with This Genotype
Genotype
MGI:3850059
Allelic
Composition
Nlrp3tm1Flv/Nlrp3tm1Hhf
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (7 available); any Lyz2 mutation (11 available)
Nlrp3tm1Flv mutation (0 available); any Nlrp3 mutation (24 available)
Nlrp3tm1Hhf mutation (1 available); any Nlrp3 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between 2 and 14 days after birth probably due to multisystem organ failure secondary to inflammation and necrosis
• genotype demonstrates inflammatory disease of the conditional allele does not require presence of wild-type allele

immune system
• mice have pronounced leukocytic infiltrates in skin, liver, spleen, joint, sinus, conjunctiva, bone marrow, and tongue that are mainly neutrophilic

Mouse Models of Human Disease
OMIM ID Ref(s)
Muckle-Wells Syndrome; MWS 191900 J:150054


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory