Phenotypes Associated with This Genotype

Genotype
MGI:3850056

• Allelic Composition: Nlrp3^tm1Hhf/Nlrp3⁺; Rag1^tm1Mom/Rag1^tm1Mom; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:150054 )

• mice die between 2 and 14 days after birth probably due to multisystem organ failure secondary to inflammation and necrosis

• 70% of mice die between 7-14 days

• absence of B and T cells demonstrates disease is not caused by the adaptive immune system

growth/size/body

slow postnatal weight gain ( J:150054 )

• mutant pups gained weight slowly, and then lost weight before dying

immune system

absent B cells ( J:150054 )

absent T cells ( J:150054 )

hematopoietic system

absent B cells ( J:150054 )

absent T cells ( J:150054 )

integument

reddish skin ( J:150054 )

• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4

scaly skin ( J:150054 )

• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4