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Phenotypes Associated with This Genotype
Genotype
MGI:3850053
Allelic
Composition		 Il1r1tm1Roml/Il1r1tm1Roml
Nlrp3tm1Hhf/Nlrp3+
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Roml mutation (2 available); any Il1r1 mutation (38 available)
Lyz2tm1(cre)Ifo mutation (16 available); any Lyz2 mutation (40 available)
Nlrp3tm1Hhf mutation (1 available); any Nlrp3 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:150054 )
N
• postnatal lethality does not occur to mice on a IL-1 receptor null background

immune system
skin inflammation ( J:150054 )
• variable skin inflammation is observed

integument
skin inflammation ( J:150054 )
• variable skin inflammation is observed

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory