Phenotypes Associated with This Genotype

Genotype
MGI:3850045

• Allelic Composition: Nlrp3^tm1Hhf/Nlrp3⁺; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:150054 )

• mice die between 2 and 14 days after birth probably due to multisystem organ failure secondary to inflammation and necrosis

• 70% of mice die between 7-14 days

growth/size/body

slow postnatal weight gain ( J:150054 )

• mutant pups gained weight slowly, and then lost weight before dying

digestive/alimentary system

abnormal intestine morphology ( J:150054 )

• substantial necrosis occurs in the gut that is not associated with inflammation

renal/urinary system

abnormal kidney morphology ( J:150054 )

• substantial necrosis occurs in the kidney that is not associated with inflammation

immune system

increased leukocyte cell number ( J:150054 )

• white blood cell count is mildly elevated

increased neutrophil cell number ( J:150054 )

• pronounced neutrophilia is evident in these mice

abnormal circulating cytokine level ( J:150054 )

• GCSF is elevated in the sera of 6-8 day old mice

abnormal circulating chemokine level ( J:150054 )

• CXCL1 levels are elevated in the sera of mice 6-8 days old

increased circulating interleukin-1 beta level ( J:150054 )

• IL-1beta levels in the sera of 6-8 day old mice are elevated 3-fold

• levels of this cytokine are also elevated in the dermis and epidermis, which may contribute to the skin pathology

increased circulating interleukin-18 level ( J:150054 )

• IL-18 levels are elevated in the sera of 6-8 day old mice

increased circulating interleukin-6 level ( J:150054 )

• IL-6 levels are elevated in the sera of 6-8 day old mice

• levels of this cytokine are also elevated in the dermis and epidermis, which may contribute to the skin pathology

increased circulating tumor necrosis factor level ( J:150054 )

• TNF levels in the sera of 6-8 day old mice are elevated

increased inflammatory response ( J:150054 )

• mice have pronounced leukocytic infiltrates in skin, liver, spleen, joint, sinus, conjunctiva, bone marrow, and tongue that are mainly neutrophilic

homeostasis/metabolism

abnormal circulating cytokine level ( J:150054 )

• GCSF is elevated in the sera of 6-8 day old mice

abnormal circulating chemokine level ( J:150054 )

• CXCL1 levels are elevated in the sera of mice 6-8 days old

increased circulating interleukin-1 beta level ( J:150054 )

• IL-1beta levels in the sera of 6-8 day old mice are elevated 3-fold

• levels of this cytokine are also elevated in the dermis and epidermis, which may contribute to the skin pathology

increased circulating interleukin-18 level ( J:150054 )

• IL-18 levels are elevated in the sera of 6-8 day old mice

increased circulating interleukin-6 level ( J:150054 )

• IL-6 levels are elevated in the sera of 6-8 day old mice

• levels of this cytokine are also elevated in the dermis and epidermis, which may contribute to the skin pathology

increased circulating tumor necrosis factor level ( J:150054 )

• TNF levels in the sera of 6-8 day old mice are elevated

hematopoietic system

thrombocytosis ( J:150054 )

• thrombocytosis is evident in these mice

increased leukocyte cell number ( J:150054 )

• white blood cell count is mildly elevated

increased neutrophil cell number ( J:150054 )

• pronounced neutrophilia is evident in these mice

integument

hairless ( J:150054 )

• hair growth does not occur in these mice

reddish skin ( J:150054 )

• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4

scaly skin ( J:150054 )

• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4