About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3850045
Allelic
Composition
Nlrp3tm1Hhf/Nlrp3+
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (7 available); any Lyz2 mutation (9 available)
Nlrp3tm1Hhf mutation (1 available); any Nlrp3 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between 2 and 14 days after birth probably due to multisystem organ failure secondary to inflammation and necrosis (J:150054)
• 70% of mice die between 7-14 days (J:150054)
• mice die between 2 and 14 days after birth probably due to multisystem organ failure secondary to inflammation and necrosis (J:150054)
• 70% of mice die between 7-14 days (J:150054)

growth/size/body
• mutant pups gained weight slowly, and then lost weight before dying (J:150054)
• mutant pups gained weight slowly, and then lost weight before dying (J:150054)

digestive/alimentary system
• substantial necrosis occurs in the gut that is not associated with inflammation (J:150054)
• substantial necrosis occurs in the gut that is not associated with inflammation (J:150054)

renal/urinary system
• substantial necrosis occurs in the kidney that is not associated with inflammation (J:150054)
• substantial necrosis occurs in the kidney that is not associated with inflammation (J:150054)

immune system
• white blood cell count is mildly elevated (J:150054)
• white blood cell count is mildly elevated (J:150054)
• pronounced neutrophilia is evident in these mice (J:150054)
• pronounced neutrophilia is evident in these mice (J:150054)
• GCSF is elevated in the sera of 6-8 day old mice (J:150054)
• GCSF is elevated in the sera of 6-8 day old mice (J:150054)
• CXCL1 levels are elevated in the sera of mice 6-8 days old (J:150054)
• CXCL1 levels are elevated in the sera of mice 6-8 days old (J:150054)
• IL-1beta levels in the sera of 6-8 day old mice are elevated 3-fold (J:150054)
• levels of this cytokine are also elevated in the dermis and epidermis, which may contribute to the skin pathology (J:150054)
• IL-1beta levels in the sera of 6-8 day old mice are elevated 3-fold (J:150054)
• levels of this cytokine are also elevated in the dermis and epidermis, which may contribute to the skin pathology (J:150054)
• IL-18 levels are elevated in the sera of 6-8 day old mice (J:150054)
• IL-18 levels are elevated in the sera of 6-8 day old mice (J:150054)
• levels of this cytokine are also elevated in the dermis and epidermis, which may contribute to the skin pathology (J:150054)
• IL-6 levels are elevated in the sera of 6-8 day old mice (J:150054)
• IL-6 levels are elevated in the sera of 6-8 day old mice (J:150054)
• levels of this cytokine are also elevated in the dermis and epidermis, which may contribute to the skin pathology (J:150054)
• TNF levels in the sera of 6-8 day old mice are elevated (J:150054)
• TNF levels in the sera of 6-8 day old mice are elevated (J:150054)
• mice have pronounced leukocytic infiltrates in skin, liver, spleen, joint, sinus, conjunctiva, bone marrow, and tongue that are mainly neutrophilic (J:150054)
• mice have pronounced leukocytic infiltrates in skin, liver, spleen, joint, sinus, conjunctiva, bone marrow, and tongue that are mainly neutrophilic (J:150054)

homeostasis/metabolism
• GCSF is elevated in the sera of 6-8 day old mice (J:150054)
• GCSF is elevated in the sera of 6-8 day old mice (J:150054)
• CXCL1 levels are elevated in the sera of mice 6-8 days old (J:150054)
• CXCL1 levels are elevated in the sera of mice 6-8 days old (J:150054)
• IL-1beta levels in the sera of 6-8 day old mice are elevated 3-fold (J:150054)
• levels of this cytokine are also elevated in the dermis and epidermis, which may contribute to the skin pathology (J:150054)
• IL-1beta levels in the sera of 6-8 day old mice are elevated 3-fold (J:150054)
• levels of this cytokine are also elevated in the dermis and epidermis, which may contribute to the skin pathology (J:150054)
• IL-18 levels are elevated in the sera of 6-8 day old mice (J:150054)
• IL-18 levels are elevated in the sera of 6-8 day old mice (J:150054)
• IL-6 levels are elevated in the sera of 6-8 day old mice (J:150054)
• levels of this cytokine are also elevated in the dermis and epidermis, which may contribute to the skin pathology (J:150054)
• IL-6 levels are elevated in the sera of 6-8 day old mice (J:150054)
• levels of this cytokine are also elevated in the dermis and epidermis, which may contribute to the skin pathology (J:150054)
• TNF levels in the sera of 6-8 day old mice are elevated (J:150054)
• TNF levels in the sera of 6-8 day old mice are elevated (J:150054)

hematopoietic system
• thrombocytosis is evident in these mice (J:150054)
• thrombocytosis is evident in these mice (J:150054)
• white blood cell count is mildly elevated (J:150054)
• white blood cell count is mildly elevated (J:150054)
• pronounced neutrophilia is evident in these mice (J:150054)
• pronounced neutrophilia is evident in these mice (J:150054)

integument
• hair growth does not occur in these mice (J:150054)
• hair growth does not occur in these mice (J:150054)
• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4 (J:150054)
• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4 (J:150054)
• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4 (J:150054)
• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4 (J:150054)

Mouse Models of Human Disease
OMIM ID Ref(s)
Muckle-Wells Syndrome; MWS 191900 J:150054


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory