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Phenotypes Associated with This Genotype
Genotype
MGI:3850044
Allelic
Composition
Nlrp3tm1Hhf/Nlrp3+
Tg(Zp3-cre)3Mrt/?
Genetic
Background
involves: 129/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3tm1Hhf mutation (1 available); any Nlrp3 mutation (26 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between 2 and 14 days after birth probably due to multisystem organ failure secondary to inflammation and necrosis

growth/size/body
• mutant pups gained weight slowly, and then lost weight before dying

immune system
• white blood cell count is mildly elevated
• pronounced neutrophilia is evident in these mice
• mice have pronounced leukocytic infiltrates in skin, liver, spleen, joint, sinus, conjunctiva, bone marrow, and tongue that are mainly neutrophilic

digestive/alimentary system
• substantial necrosis occurs in the gut that is not associated with inflammation

renal/urinary system
• substantial necrosis occurs in the kidney that is not associated with inflammation

hematopoietic system
• thrombocytosis is evident in these mice
• white blood cell count is mildly elevated
• pronounced neutrophilia is evident in these mice

integument
• hair growth does not occur in these mice
• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4
• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4

Mouse Models of Human Disease
OMIM ID Ref(s)
Muckle-Wells Syndrome; MWS 191900 J:150054


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory