Mouse Genome Informatics
cn
    Nlrp3tm1Hhf/Nlrp3+
Tg(Zp3-cre)3Mrt/?

involves: 129/Sv * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mice die between 2 and 14 days after birth probably due to multisystem organ failure secondary to inflammation and necrosis

growth/size/body
• mutant pups gained weight slowly, and then lost weight before dying

immune system
• white blood cell count is mildly elevated
• pronounced neutrophilia is evident in these mice
• mice have pronounced leukocytic infiltrates in skin, liver, spleen, joint, sinus, conjunctiva, bone marrow, and tongue that are mainly neutrophilic

digestive/alimentary system
• substantial necrosis occurs in the gut that is not associated with inflammation

renal/urinary system
• substantial necrosis occurs in the kidney that is not associated with inflammation

hematopoietic system
• white blood cell count is mildly elevated
• pronounced neutrophilia is evident in these mice
• thrombocytosis is evident in these mice

integument
• hair growth does not occur in these mice
• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4
• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4

Mouse Models of Human Disease
OMIM IDRef(s)
Muckle-Wells Syndrome; MWS 191900 J:150054