Phenotypes Associated with This Genotype

Genotype
MGI:3850044

• Allelic Composition: Nlrp3^tm1Hhf/Nlrp3⁺; Tg(Zp3-cre)3Mrt/?
• Genetic Background: involves: 129/Sv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:150054 )

• mice die between 2 and 14 days after birth probably due to multisystem organ failure secondary to inflammation and necrosis

growth/size/body

slow postnatal weight gain ( J:150054 )

• mutant pups gained weight slowly, and then lost weight before dying

immune system

increased leukocyte cell number ( J:150054 )

• white blood cell count is mildly elevated

increased neutrophil cell number ( J:150054 )

• pronounced neutrophilia is evident in these mice

increased inflammatory response ( J:150054 )

• mice have pronounced leukocytic infiltrates in skin, liver, spleen, joint, sinus, conjunctiva, bone marrow, and tongue that are mainly neutrophilic

digestive/alimentary system

abnormal intestine morphology ( J:150054 )

• substantial necrosis occurs in the gut that is not associated with inflammation

renal/urinary system

abnormal kidney morphology ( J:150054 )

• substantial necrosis occurs in the kidney that is not associated with inflammation

hematopoietic system

thrombocytosis ( J:150054 )

• thrombocytosis is evident in these mice

increased leukocyte cell number ( J:150054 )

• white blood cell count is mildly elevated

increased neutrophil cell number ( J:150054 )

• pronounced neutrophilia is evident in these mice

integument

hairless ( J:150054 )

• hair growth does not occur in these mice

reddish skin ( J:150054 )

• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4

scaly skin ( J:150054 )

• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4