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Phenotypes Associated with This Genotype
Genotype
MGI:3849995
Allelic
Composition		 Tgfb1tm1Doe/Tgfb1tm2.1Doe
Tg(Lck-cre)548Jxm/?
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfb1tm1Doe mutation (3 available); any Tgfb1 mutation (34 available)
Tgfb1tm2.1Doe mutation (0 available); any Tgfb1 mutation (34 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Lung and salivary gland inflammation in Tgfb1tm2.1Doe/Tgfb1tm2.1Doe Tg(Lck-cre)548Jxm/? (b,e) and Tgfb1tm1Doe/Tgfb1tm2.1Doe Tg(Lck-cre)548Jxm/? (c,f) mice

immune system
salivary gland inflammation ( J:150024 )
• salivary gland inflammation is observed in mice at 5 months of age
lung inflammation ( J:150024 )
• inflammation is observed in the lungs at 5 months of age

respiratory system
lung inflammation ( J:150024 )
• inflammation is observed in the lungs at 5 months of age

digestive/alimentary system
salivary gland inflammation ( J:150024 )
• salivary gland inflammation is observed in mice at 5 months of age

endocrine/exocrine glands
salivary gland inflammation ( J:150024 )
• salivary gland inflammation is observed in mice at 5 months of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory