mortality/aging
• Background Sensitivity: mice exhibit 27% lethality within the first 4 weeks of life compared to 11% on a congenic FVB background and 47% on a congenic C57BL/6 background
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behavior/neurological
• male and female mice exhibit increased aggression compared with wild-type mice
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• female mice exhibit aggression towards other females unlike wild-type mice
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• during the first hour of exposure to cold conditions
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• during the daytime, mice sleep more frequently and for longer periods compared with wild-type mice
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• within days of birth of giving birth, mothers begin to exhibit neglect of their young and often cannibalize them
• however, at birth mothers nurse pups and organize and keep a nest
• most pups of homozygous mothers are dead within 2 to 3 days after birth
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• at P1, 8 of 9 mothers fail to retrieve scattered young within 30 minutes unlike wild-type mothers
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• in cross-fostering experiments, mothers cannibalize 30% of whole litters born by wild-type mothers unlike wild-type mothers fostering pups born from homozygous mothers
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homeostasis/metabolism
• following exposure to cold, mice exhibit a more pronounced drop in body temperature than similarly treated wild-type mice
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• until 2 months of age
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• 5-HT levels in the striatum, frontal cortex, hippocampus, and hypothalamus are lower than in wild-type mice
• however, 5-HT levels in the duodenum, liver, blood, and spleen are normal
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growth/size/body
• mice exhibit reduced body size at P3 compared to in wild-type
• handling, including food quantification and force feeding, worsens the phenotype
• however, mice reach normal size by 4 months
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• weaning is delayed by 2 weeks
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cardiovascular system
• during the nighttime
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• during the nighttime
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respiratory system
• respiration rate (breaths per minute) is decreased compared to in wild-type mice
• however, the circadian rhythm of respiration rates is normal
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nervous system
• autonomic control of sleep, breathing, thermoregulation, heart rate, and blood pressure is impaired
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taste/olfaction
N |
• female mice exhibit normal olfaction in a hidden cookie challenge
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integument
• mice exhibit softer skin than wild-type mice
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