Phenotypes Associated with This Genotype

Genotype
MGI:3849428

• Allelic Composition: Mecom^tm1Miku/Mecom^tm1Miku; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal platelet morphology ( J:149794 )

• platelets have delayed recovery of numbers after administration of Fluorouracil

thrombocytopenia ( J:149794 )

• platelet cell number is moderately decreased compared to controls 4 weeks after cre induction

abnormal hematopoietic stem cell morphology ( J:149794 )

• bone marrow HSC have reduced proliferation relative to controls when cultured in vitro

• both accelerated apoptosis and impaired cell cycling occur in these cells

• increased rates of apoptosis are observed in vivo in the fetal liver after cre induction

decreased hematopoietic stem cell number ( J:149794 )

• HSC and CFU numbers in the bone marrow significantly decrease after cre induction

• 12 weeks after induction, HSC numbers have recovered but consist entirely of HSC that have escaped cre-mediated excision of the gene locus