Phenotypes Associated with This Genotype

Genotype
MGI:3849426

• Allelic Composition: Mecom^tm1Miku/Mecom^tm1Miku; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: C3H * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:149794 )

• lethality occurs between E13.5 and E16.5 for most embryos

• a few mice reach adulthood due to the presence of bone marrow cells that escape cre mediated excision

cardiovascular system

hemorrhage ( J:149794 )

• many E13.5 embryos exhibit hemorrhaging

hematopoietic system

decreased hematopoietic stem cell number ( J:149794 )

• the population of lin^- Kit⁺CD34⁺ found among E14.5 fetal liver cells is severely reduced

• the number of myeloid or mixed CFUs isolated from fetal liver is also diminished

homeostasis/metabolism

skin edema ( J:149794 )

• many E13.5 embryos exhibit subcutaneous edema

integument

skin edema ( J:149794 )

• many E13.5 embryos exhibit subcutaneous edema