Phenotypes Associated with This Genotype

Genotype
MGI:3848967

• Allelic Composition: Hand2^tm1Cse/Hand2^tm1Dsr; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:122604 )

• embryos begin to die by 12 dpc and no live embryos are recovered at 13 dpc

cardiovascular system

visceral vascular congestion ( J:122604 )

• blood pools in major vessels, heart, liver, and coelom by 12 dpc

abnormal blood circulation ( J:122604 )

• circulatory defects develop by 12 dpc

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:122604 )

• number of neuronal cells in sympathetic nervous system expressing tyrosine hydroxylase or dopamine beta-hydroxylase is greatly reduced compared to controls at 12.5 dpc

nervous system

nervous system phenotype ( J:122604 )

N • neural crest cell colonization of the sympathetic nervous system is normal, and sympathetic nervous system differentiation is unaffected in mutant embryos

abnormal adrenergic neuron morphology ( J:122604 )

• catecholaminergic differentiation of the sympathetic nervous system is abnormal in mutants; fewer neurons produce enzymes needed for synthesis of noradrenaline than in wild-type controls