Analysis Tools
hematopoietic system
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• pIpC-treated bone marrow cells fails to contribute to hematopoiesis in a competitively reconstituted bone marrow recipient unlike wild-type cells
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• following pIpC treatment, mice exhibit a reduction in lymphoid progenitor cells compared with wild-type mice
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• pIpC induction, lymphocyte are depleted and fail to regenerate unlike in similarly treated wild-type mice
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• 2 weeks after pIpC induction, the number of hematopoietic stem cell-containing LSK populations is decreased compared to in similarly treated wild-type mice
• following pIpC treatment, mice exhibit a reduction in hematopoietic stem cells, specifically self-renewing long-term and short-term hematopoietic stem cells and lymphoid progenitor cells, compared with wild-type mice
• however, proliferation of pIpC-treated erythroid-myeloid progenitor cells is normal
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• following pIpC treatment, hematopoietic stem cell apoptosis is increased compared to in similarly treated wild-type mice
• following pIpC treatment, maintenance of adult hematopoietic cells is abolished compared to in similarly treated wild-type mice
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immune system
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• pIpC induction, lymphocyte are depleted and fail to regenerate unlike in similarly treated wild-type mice
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