Mouse Genome Informatics
hm
    Glis3tm1Amj/Glis3tm1Amj
involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mice die by P12

renal/urinary system
• dilated tubules exhibit a reduction in cilium lining compared with wild-type tubules
• between E14.5 and E15.5, Bowman's spaces are dilated unlike in wild-type mice
• dilated tubules exhibit a reduction in cilium lining compared with wild-type tubules
• at P3, mice develop tubular and glomerular cysts unlike wild-type mice
• polycystic kidney disease worsens with age
• cysts originate from the glomeruli, tubules, and collecting ducts
• cell proliferation of the glomerulocyst epithelium lining is increased compared to the proliferation of wild-type Bowman's space lining
• cysts exhibit a reduction in cilium lining compared to in wild-type renal linings

homeostasis/metabolism
• in neonates due to a deficiency in the generation of pancreatic beta-cells
• in neonates due to a deficiency in the generation of pancreatic beta-cells

growth/size/body

cellular
• dilated tubules exhibit a reduction in cilium lining compared with wild-type tubules

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Neonatal, with Congenital Hypothyroidism 610199 J:148994