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Phenotypes Associated with This Genotype
Genotype
MGI:3848057
Allelic
Composition
Glis3tm1Amj/Glis3tm1Amj
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glis3tm1Amj mutation (0 available); any Glis3 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

renal/urinary system
• dilated tubules exhibit a reduction in cilium lining compared with wild-type tubules
• between E14.5 and E15.5, Bowman's spaces are dilated unlike in wild-type mice
• dilated tubules exhibit a reduction in cilium lining compared with wild-type tubules
• at P3, mice develop tubular and glomerular cysts unlike wild-type mice
• polycystic kidney disease worsens with age
• cysts originate from the glomeruli, tubules, and collecting ducts
• cell proliferation of the glomerulocyst epithelium lining is increased compared to the proliferation of wild-type Bowman's space lining
• cysts exhibit a reduction in cilium lining compared to in wild-type renal linings

homeostasis/metabolism
• in neonates due to a deficiency in the generation of pancreatic beta-cells
• in neonates due to a deficiency in the generation of pancreatic beta-cells

growth/size/body

cellular
• dilated tubules exhibit a reduction in cilium lining compared with wild-type tubules


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory