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Phenotypes Associated with This Genotype
Genotype
MGI:3847955
Allelic
Composition		 Nr0b2tm1Mjev/Nr0b2tm1Mjev
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S/SvEvBrd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr0b2tm1Mjev mutation (0 available); any Nr0b2 mutation (15 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating cholesterol level ( J:149005 )
• when fed a high cholesterol diet with cholic acid diet
decreased circulating LDL cholesterol level ( J:149005 )
• either when fed a high cholesterol diet with cholic acid diet or an iodine-deficient diet compared to similarly treated Nr0b2tm1Mjev homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory