Analysis Tools
mortality/aging
|
• the percentage of homozygous embryos is less than normal, approximately 15% from a heterozygous intercross
|
reproductive system
|
• Background Sensitivity: gonads are depleted of germ cells at birth and this has varying penetrance with greater severity on the CAST/EiJ background than the C57BL/6J background
• by embryonic day 11.5 there is a significant reduction in the average number of primordial germ cells and by embryonic day 11.5, after the proliferative phase of primordial germ cell development is normally complete, there are, on average, fewer than half the normal number of primordial germ cells
|
infertility
(
J:111998
)
|
• Background Sensitivity: at the 7th to 9th backcross generation on CAST/EiJ sterility is 90% penetrant
|
cellular
|
• Background Sensitivity: gonads are depleted of germ cells at birth and this has varying penetrance with greater severity on the CAST/EiJ background than the C57BL/6J background
• by embryonic day 11.5 there is a significant reduction in the average number of primordial germ cells and by embryonic day 11.5, after the proliferative phase of primordial germ cell development is normally complete, there are, on average, fewer than half the normal number of primordial germ cells
|
