Phenotypes for Gli2 Gli3 MGI:3846354 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gli2^{tm3.1(Gli1)Alj}/Gli2⁺ Gli3^Xt-J/Gli3⁺
Genetic Background	either: (involves: 129S6/SvEvTac * C3H/HeJ) or (involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^{tm3.1(Gli1)Alj} mutation (0 available); any Gli2 mutation (169 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:73074 )

• females die by 6 weeks of age

limbs/digits/tail

polydactyly ( J:73074 )

• polydactyl is enhanced compared to mice heterozygous for Gli3^Xt-J alone

reproductive system

male infertility ( J:73074 )

• all males are sterile

integument

progressive hair loss ( J:73074 )

• hair loss is more severe compared to mice heterozygous for Gli2^{tm3.1(Gli2)Alj} alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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