Phenotypes Associated with This Genotype

Genotype
MGI:3845792

• Allelic Composition: Hr^Tg5053Mm/Hr^Tg5053Mm
• Genetic Background: involves: C3H/He * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

progressive hair loss ( J:15642 )

• beginning at P19 on the head and progressing caudally with age until complete loss of hair by 1 month of age

hair follicle degeneration ( J:15642 )

skin lesions ( J:15642 )

• several older mice develop crusted erosions between forelegs with underlying subcutaneous nodules consisting of lymph nodes and complications including wasting, increased respiratory rate, and lethargy

• however, treatment with topical antibiotic ointment prevents complications

wrinkled skin ( J:15642 )

• extensively with age

abnormal skin condition ( J:15642 )

• at 1 month, mice exhibit dilated cystic or cup-shaped structures termed utriculi

epidermal cyst ( J:15642 )

• dermal cysts grow with age

thick skin ( J:15642 )

• with age

growth/size/body

epidermal cyst ( J:15642 )

• dermal cysts grow with age