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Phenotypes Associated with This Genotype
Genotype
MGI:3845769
Allelic
Composition		 Otx1tm2(otd)Asim/Otx1tm2(otd)Asim
Otx2tm1Pas/Otx2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx1tm2(otd)Asim mutation (1 available); any Otx1 mutation (86 available)
Otx2tm1Pas mutation (2 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal midbrain morphology ( J:47899 )
• mice exhibit severe perturbation in the posterior mesencephalon
• however, mice exhibit an improvement in the dorsal thalamus, pretectal area, and anterior mesencephalon morphology compared to in Otx1tm1Asim/Otx1tm1Asim Otx2tm1Pas/Otx2+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory